S-acylation of sprouty and spred proteins by the s-acyltransferase zdhhc17 involves a novel mode of enzyme-substrate interaction

HIGHLIGHTS

• who: Liam Butler from the (UNIVERSITY) have published the research: S-acylation of Sprouty and SPRED proteins by the S-acyltransferase zDHHC17 involves a novel mode of enzyme-substrate interaction, in the Journal: (JOURNAL) of October/14,/2022
• what: The aim of this study was to investigate the interaction of Spry2 with zDHHC17 to determine if recognition and subsequent S-acylation occurred by the same pathway/mechanism described for SNAP25. The authors propose for Spry2 and SPRED1/2 that zDHHC17 interaction with the zDABM does not align the cysteine-rich region and the catalytic DHHC . . .
  

   

  

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