HIGHLIGHTS
- who: Sprague Dawley rats and collaborators from the Salk Institute for Biological Studies, United States The Pennsylvania State University have published the research: S-Nitroso-L-Cysteine Stereoselectively Blunts the Deleterious Effects of Fentanyl on Breathing While Augmenting Antinociception in Freely-Moving Rats, in the Journal: (JOURNAL)
- what: The authors report surprising, but intriguing, findings related to the ability of the peripherally restricted OR antagonist, naloxone methiodide (NLXmi) (Lewanowitsch and Irvine, 2002; Lewanowitsch, et_al, 2006; Henderson et_al, 2014), to markedly increase fR in rats that had received prior injections of fentanyl, but not vehicle. Pharmacological . . .
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