HIGHLIGHTS
SUMMARY
Chronic inflammation is the core mechanism of the development of chronic obstructive pulmonary disease (COPD). Three types of data, including basic information of included studies, pre-defined outcome data, and quality assessment information were extracted. Corticosteroid resistance (Chung, 2011). p38 MAPK overexpression has also been found in lung tissue and correlated with poorer lung function in the COPD population (Renda et_al, 2008; Gaffey et_al, 2013). In the rat model, p38 MAPKIs showed a promising effect on inhibiting airway inflammation (Escott et_al, 2000; Duan et_al, 2005). A hypothesis emerged that p38 MAPKIs might slow down . . .
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