Safety and efficacy of monthly high-dose vitamin d3 supplementation in children and adolescents with sickle cell disease

HIGHLIGHTS

  • What: The authors aimed to evaluate the safety and efficacy of monthly high-dose vitamin D ­ 3 supplementation and its implications on bone mineral density (BMD) and HRQoL in patients with SCD and healthy controls.
  • Who: Diana Hanna from the We enrolled , children with SCD (HbSS, HbSβ, thalassemia genotype), aged ≤ , years old, male or female at a steady state (≥ , month from blood transfusion and ≥ , days following one of the SCD complications as hospitalization for VOC or acute chest syndrome (ACS)), stable hemoglobin (Hb) level near their usual baseline, and stable dose of hydroxyurea (mg/kg . . .

     

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