Safety and immunogenicity of plant-produced african horse sickness virus-like particles in horses

HIGHLIGHTS

• who: Susan J. Dennis from the ground up in, × PBS containing, × protease inhibitor (PI) cocktail , (Sigma Life Science) and incubated overnight at , °C to allow for completion of VLP assemblyVLPs were purified by density gradient ultracentrifugation and TEM used to verify their similarity in structure to native AHS virions. Vaccination of guinea pigs with these AHS , VLPs proved to be completely safe and induced a high neutralizing antibody response in the animal model. The aim of the present study was to test the safety and immunogenicity of this VLP candidate vaccine in horses, and to consider ways . . .
  

   

  

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