Samhd1 enhances chikungunya and zika virus replication in human skin fibroblasts

HIGHLIGHTS

  • who: Sineewanlaya Wichit and collaborators from the Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Nakhon Pathom, Thailand have published the Article: SAMHD1 Enhances Chikungunya and Zika Virus Replication in Human Skin Fibroblasts, in the Journal: (JOURNAL)
  • what: The authors show that the expression of the interferon-stimulated proteins MX1 and ISG15 as well as expression of defense response proteins DDX58 STAT1 OAS3 EIF2AK2 and was significantly up-regulated in these cells upon infection with either Exogenous expression of IFITs proteins markedly inhibited CHIKV and ZIKV replication which accordingly was . . .

     

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