Sap97-mediated adam10 trafficking from golgi outposts depends on pkc phosphorylation

HIGHLIGHTS

• who: C Saraceno from the DepartmentSapienza University of Rome, Ple A. Moro, Rome, Italy have published the research: SAP97-mediated ADAM10 trafficking from Golgi outposts depends on PKC phosphorylation, in the Journal: (JOURNAL) of November/24,/1986
• how: In a second step the authors investigated whether SAP97 is a PKC substrate carrying out metabolic labeling experiments with orthophosphate in yellow fluorescent protein (YFP)SAP97wt-transfected COS-7 cells. To explore further how SAP97 T629 phosphorylation influences ADAM10/SAP97 binding the authors carried out a modeling study.

SUMMARY

PKC activation fosters ADAM10 . . .

 



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