HIGHLIGHTS
SUMMARY
The interferongamma release assay was originally validated to study T_cell responses following natural infection, where it displays 98% sensitivity. The discordance between the detection of vaccine- and infection-induced T_cell responses may arise from the duration, anatomy and magnitude of antigen exposure, differences in the immunological environment when antigen was presented, or assay-specific factors including differences in MHC restriction to the constituents of the peptide pool and the antigen-specific T_cell repertoire in each circumstance. Strong, polyfunctional T_cell responses have previously been shown in an XLA patient following infection, and concordant with the . . .
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