Scalable synthesis of trpv1 antagonist bipyridinyl benzimidazole derivative via the suzuki-miyaura reaction and selective seo2 oxidation

HIGHLIGHTS

• who: Joon-Hwan Lee and collaborators from the Department of Applied Chemistry, Global Center for Pharmaceutical Ingredient Materials, Kyung Hee University, Yongin, Republic of Korea have published the article: Scalable Synthesis of TRPV1 Antagonist Bipyridinyl Benzimidazole Derivative via the Suzuki-Miyaura Reaction and Selective SeO2 Oxidation, in the Journal: Molecules 2023, 836 of /2023/
• what: In this study a kilogram-scale synthesis of a potent antagonist 1 is described.
• how: The authors developed a scalable method for synthesis of compound 1 in two different routes with high yield and quality that are capable . . .
  

   

  

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