Scientific rationale for the use of α2a-adrenoceptor agonists in treating neuroinflammatory cognitive disorders

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SUMMARY

    The dlPFC subserves higher order cognitive functions such as working memory, recall memory (but not recognition memory, which is more dependent on medial temporal lobe), abstract reasoning, and the executive functions e_g planning and organization, and the regulation of attention and action. PFC cognitive deficits can range from being relatively mild (although still debilitating), e_g with executive dysfunction as the primary complaint, to very severe, e_g profound deficits in delirium. The tasks most commonly used to assess pre- vs. post-operative cognitive performance are those that depend on the functional integrity of the PFC . . .

     

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