Screening and identifying a novel m-mdscs-related gene signature for predicting prognostic risk and immunotherapeutic responses in patients with lung adenocarcinoma

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SUMMARY

    TAMs participate in angiogenesis and tumor pre-metastasis (Yang et_al, 2020; Consonni et_al, 2021). In the TME of LUAD, many studies have been focused on the prognosis of T_cells (Du et_al, 2021), B cells (Zhang et_al, 2021), cancer-associated fibroblasts (CAFs) (Navab et_al, 2011; Min et_al, 2021), and tumorassociated macrophages (TAMs) (Chen et_al, 2021), as well as the biological processes, including epithelial-mesenchymal transition (EMT) (Shi et_al, 2021) and angiogenesis (Cai et_al, 2021). M-MDSCs exert greater immunosuppressive effects relative to PMN-MDSCs, which suppress antigen-nonspecific and antigen-specific T_cell functions by generating . . .

     

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