Screening of anti-inflammatory activities components of angelica dahurica root based on spectrum-effect relationship analysis and nf-κb pathway

HIGHLIGHTS

• What: This study evaluated the antiinflammatory activities of ADR samples by inhibiting the production of NO, IL-1β, IL-6, and TNF-α in LPS-stimulated RAW264.7 macrophages. In general, the primary objective of this study was to identify the anti-inflammatory bioactive components in ADR using a comprehensive approach. This study developed a comprehensive method utilizing HPLC fingerprints, HPLC-Q/TOF-MS and spectrumeffect relationship analysis to investigate the bioactive ingredients in herbal medicines, and also provided experimental data about the bioactive compositions and underlying mechanism for the anti-inflammatory activity of ADR.
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