Scrna-seq of gastric tumor shows complex intercellular interaction with an alternative t cell exhaustion trajectory

HIGHLIGHTS

• who: Keyong Sun from the (UNIVERSITY) have published the article: scRNA-seq of gastric tumor shows complex intercellular interaction with an alternative T cell exhaustion trajectory, in the Journal: (JOURNAL) of 29/03/2021
• what: Coupled with TCR clonotype information and trajectory analysis, the authors show that Tc17 in GC possibly originate from the tissue-resident memory population and can subsequently differentiate into an exhausted state, which suggests an alternative pathway for T_cell exhaustion. To investigate the underlying mechanism driving the distinct transcriptional programs of the two trajectories (Fig 7c), the authors focused the analyses . . .
  

   

  

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