HIGHLIGHTS
- who: Aniket Jana et al. from the DepartmentBlacksburg, VA, USA Hopkins University have published the paper: Sculpting Ruptureu2010Free Nuclear Shapes in Fibrous Environments, in the Journal: (JOURNAL)
- what: The authors explore the mechanosensitivity of cells to fibrous microenvironments using nanofiber networks of precisely controlled geometries and fiber diameters. The studies showed that for similar levels of contractility but different spread areas, YAP translocation remained similar. In contrast, here, the authors demonstrate that the invagination in the nucleus occurs across the entire length of the nucleus. Under these conditions, the authors show that while fiber curvature . . .
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