SUMMARY
(Chen et_al, 2018; Heurling et_al, 2019; Holmes et_al, 2019; Mecca et_al, 2020; Onwordi et_al, 2020; Michiels et_al, 2021). (Xu and Bajjalieh, 2001; Schivell et_al, 2005; Custer et_al, 2006; Chang and Südhof, 2009; Yao et_al, 2010). (Yang and Rothman, 2009; Yang et_al, 2015). (Löscher et_al, 2016). (Lynch et_al, 2004; Matagne et_al, 2008). In Part B target occupancy in the brain was measured by PETscans (GE Signa) with the PET-ligand -UCB-J (Nabulsi et_al, 2016; Koole et_al, 2019) at three different time points: pre-dose, around Tmax (estimated on data collected in Part A), and approximately . . .
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