HIGHLIGHTS
- who: Beyond Inhibitors and collaborators from the (UNIVERSITY) have published the paper: Second-Generation Pharmacological Chaperones:, in the Journal: (JOURNAL)
- future: Studies including for instance crystallographic data would be necessary to demonstrate the allosteric binding of N-butyl-l-deoxynojirimycin. Several promising Gcase non-inhibitory PCs have been uncovered and investigated for GD1 GD2 but also Parkinson disease and further pharmaco-kinetic and -dynamic studies are needed to 6 of 21 develop the most effective analogs as well as mechanistic studies to identify the allosteric binding_sites involved.
SUMMARY
If most of . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.