Second passage experiments of chronic wasting disease in transgenic mice overexpressing human prion protein

HIGHLIGHTS

• who: Brent Race from the (UNIVERSITY) have published the research work: Second passage experiments of chronic wasting disease in transgenic mice overexpressing human prion protein, in the Journal: (JOURNAL)
• what: The PrPKO mice used in this study have been described previously as C57BL10/SnJPrnp-/- and do not express any prion protein.
• how: The results showed that the seeding activity observed in the initial experiments was likely not input inoculum and that brain material from weakly positive mice was not infectious on second passage to transgenic mice expressing human prion protein suggesting the existence . . .
  

   

  

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