Secretase-dependent tyrosine phosphorylation of mdm2 by the erbb-4 intracellular domain fragment*

HIGHLIGHTS

• who: Rajeswara Rao Arasada from the Materials-Heregulin ␤, was purchased from R and D SystemsThe ␥-secretase inhibitor Compound E was a generous gift from Todd Golde (Mayo Clinic, Jacksonville, FL). Anti-ErbB-4, anti-Mdm2, anti-p21, and anti-Shc were purchased from Santa Cruz. Anti-Shc and anti-phosphotyrosine were from BD Laboratories, and FLAG and ␤-tubulin antibodies were obtained from Sigma. Anti-p, was from BD Biosciences. HIp, cells were a gift from Jennifer Pietenpol (Vanderbilt University). D , cells expressing Erb, (Jma Cyt, isoform) were obtained from James Staros (Vanderbilt University). Plasmid Constructs-The pEGFPs . . .
  

   

  

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