Secreted and tumour targeted human carboxylesterase for activation of irinotecan

HIGHLIGHTS

  • who: CPT- and collaborators from the Division of Gene Therapy, Department of Medical Oncology, Vrije Universiteit Medical Center, , MB, Amsterdam, The NetherlandsDepartment of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan have published the research work: Secreted and tumour targeted human carboxylesterase for activation of irinotecan, in the Journal: (JOURNAL) of 18/03/2002
  • how: In vitro results showed that several tumour cell lines infected with this virus express CE1 and in the presence of CPT-11 tumour growth was effectively suppressed.

SUMMARY

    To achieve efficient kill of all tumour . . .

     

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