HIGHLIGHTS
- who: Liang Zhao and collaborators from the University of Nebraska Medical Center, United States have published the article: Secreted glucose regulated protein78 ameliorates DSS-induced mouse colitis, in the Journal: (JOURNAL)
- what: This study explored the expression pattern and functional outcome of intestinal GRP78 in IBD. The authors provide evidence that administration of sGRP78, which is evidently downregulated in both experimental and human IBD, protects against inflammation in the DSS colitis model in a preventive manner. Although further studies are required to better define the sGRP78 anti-inflammatory effects in UC onset/progression, the authors . . .
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