HIGHLIGHTS
- who: Wilhelm Palm and colleagues from the University of Dresden, Dresden, Germany have published the paper: Secretion and Signaling Activities of Lipoprotein- Associated Hedgehog and Non-Sterol-Modified Hedgehog in Flies and Mammals, in the Journal: (JOURNAL) of March/12,/2013
- what: The authors show that mammalian lipoproteins have conserved roles in Sonic Hedgehog (Shh) release and pathway repression. The authors demonstrate that lipoprotein-associated forms of Hh and Shh specifically block lipoprotein-mediated pathway inhibition. The authors show that different fly and mammalian cell types, including Shh-dependent cancer cells, release lipid-modified Hh . . .
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