Seeing is believing: dna zipping promotes dna repair

HIGHLIGHTS

  • who: Petr Cejka from the Institute8093, Switzerland have published the article: Seeing is believing: DNA zipping promotes DNA repair, in the Journal: (JOURNAL)
  • how: With dsDNA two important observations were made.

SUMMARY

    Published EDITORS' PICK HIGHLIGHT: DNA zipping promotes DNA repair not fully unambiguous because Ctp1 (and Sae2/CtIP) also interacts with and stimulates the nuclease activity of Mre11. The domains, which are necessary for DNA binding by Ctp1 and its orthologues, are also likely important to promote the nuclease function of Mre11. More structural and biochemical insights are needed to . . .

     

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