Segmentation strategy of de novo designed four-helical bundles expands protein oligomerization modalities for cell regulation

HIGHLIGHTS

• who: Estera Merljak from the (UNIVERSITY) have published the Article: Segmentation strategy of de novo designed four-helical bundles expands protein oligomerization modalities for cell regulation, in the Journal: (JOURNAL) of 30/Nov/2022
• what: While four-helical bundle proteins (4HB) have typically been assembled from two segments, each comprising two helices, here the authors show that they can be efficiently segmented in various ways, expanding the number of combinations generated from a single 4HB. The authors implement a segmentation strategy of 4HB to design two-, three-, or four-chain combinations for the recruitment of . . .
  

   

  

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