Selection of olduvai domains during evolution: a role for primate-specific splicing super-enhancer and rna guanine quadruplex in bipartite nbpf exons

HIGHLIGHTS

• who: Igor Vou0159echovsku00fd from the ESE/ESSseq scores were derived from exon inclusion levels measured by the RNA-seq of unspliced and spliced central minigene exons that contained comprehensive libraries of , hexamers cloned at five different positions [8]Briefly, the variant minigene library (input) was transfected into human embryonic kidney cells and , h later the messenger RNA molecules that had included the central exon (output) were isolated by size selection and sequenced [8]. For each hexamer, an enrichment of output proportion over input proportion was calculated and expressed as ESEseq and ESSseq scores [8]. Greater ESE/ESSseq . . .
  

   

  

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