Selective activation of gαob by an adenosine a1 receptor agonist elicits analgesia without cardiorespiratory depression

HIGHLIGHTS

• who: Mark J. Wall from the SchoolUniversity of DS, UK have published the paper: Selective activation of Gu03b1ob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show, utilising molecular dynamics (MD) simulations, and Gu03b1i/o subunit- and u03b2-arrestin-specific cellular signalling assays, how one A1R-selective agonist, BnOCPA33,34, fulfils the criteria for a selective Gu03b1 agonist in exclusively activating Gob among the six members of the Gu03b1i/o family of G protein subunits, and in the absence of u03b2-arrestin . . .
  

   

  

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