Selective inhibition of the mitochondrial permeability transition pore protects against neurodegeneration in experimental multiple sclerosis*

HIGHLIGHTS

• who: Justin Warne from the (UNIVERSITY) have published the paper: Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis*, in the Journal: (JOURNAL) of February/26,/2016
• how: To identify non-immunosuppressive doses of potential neuroprotective compounds for use in models of MS the authors employed a model using epicutaneous application of the ear skin sensitizer oxazolone to induce a T_cell proliferative response in the draining auricular lymph node peaking 3 days later (Fig 7) . The authors utilized quinolinium attached by a short alkyl chain as a mitochondrial targeting . . .
  

   

  

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