Selective targeting of il-15rα is sufficient to reduce inflammation

HIGHLIGHTS

• who: Dihia Meghnem from the , CNRS, CRCI NA, France, LabEX IGO, Immuno-Onco-Greffe, France, have published the article: Selective Targeting of IL-15Ru03b1 Is Sufficient to Reduce Inflammation, in the Journal: (JOURNAL)
• what: The authors hypothesized that retaining the binding to IL-15Ra while not recruiting IL-2Rb would block IL-15`s signaling through the trimeric IL-15Ra/IL-2Rb/gc receptor without affecting the one through the dimeric IL-2Rb/gc receptor. The authors characterized the inhibitory properties of NANTIL-15 in_vitro. This study provides evidence that selective targeting IL-15Ra chain . . .
  

   

  

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