Selective transduction of cerebellar purkinje and granule neurons using delivery of aav-php.eb and aavrh10 vectors at axonal terminal locations

HIGHLIGHTS

  • who: Maciej Figiel from the University College London, United Kingdom have published the research: Selective transduction of cerebellar Purkinje and granule neurons using delivery of AAV-PHP.eB and AAVrh10 vectors at axonal terminal locations, in the Journal: (JOURNAL)
  • what: The work aimed to find the most suitable cerebellar AAV serotypes and combine them with appropriate delivery (local and systemic) and transduction modes (direct or retrograde) to target specific cell populations in the mouse cerebellum.

SUMMARY

    The cerebellum controls muscle coordination, equilibrium, and posture, relying on various cell types and connections . . .

     

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