HIGHLIGHTS
- who: Shan Xu et al. from the University of Alabama at Birmingham, United States have published the research: Selective vulnerability of ARID1A deficient colon cancer cells to combined radiation and ATR-inhibitor therapy, in the Journal: (JOURNAL)
- what: The study shows that ARID1A- cells treated with ATRi showed significant increase in the numbers of mitotic cells after IR exposure, i.e. release from radiation induced G2 arrest. This study shows for the first time the impact of ATRi on ARID1A mutation in CRC cells, as well as in primary tumor material from CRC patients.
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.