Selective vulnerability of human-induced pluripotent stem cells to dihydroorotate dehydrogenase inhibition during mesenchymal stem/stromal cell puri cation

HIGHLIGHTS

• who: TYPE et al. from the Institute of Molecular and Cell Institute for Medical Research, University Research Center (KAIMRC), Saudi Arabia have published the research work: Selective vulnerability of human-induced pluripotent stem cells to dihydroorotate dehydrogenase inhibition during mesenchymal stem/stromal cell puri cation, in the Journal: (JOURNAL)
• what: The authors treated iMSCs with the potent DHODH inhibitor Brequinar (BRQ) and analyzed the cell survival, differentiation potential, gene_expression, and functional characteristics to determine the effectivity and safety of using the DHODH inhibitor for the elimination of unwanted hiPSCs, which will provide a fundamental step . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.