Selectivity of terpyridine platinum anticancer drugs for dna

HIGHLIGHTS

  • who: G-quadruplex et al. from the Institut Curie, PSL Research University, CNRS-UMR, INSERM, Orsay, France have published the research work: Selectivity of Terpyridine Platinum Anticancer Drugs for DNA, in the Journal: Molecules 2019, 404 of /2019/
  • what: The authors report the comparison of a panel of platinum (II) complexes for DNA selective recognition by exploring the aromatic core around terpyridine derivatives. The authors explored the chemical space around the terpyridine aromatic core to put in evidence the key elements that drive affinity and selectivity for various G4-DNA exhibiting polymorphic (22AG), antiparallel (21CTA . . .

     

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