Self-cleaving guide rnas enable pharmacological selection of precise gene editing events in vivo

HIGHLIGHTS

• who: Amita Tiyaboonchai from the Animal husbandry All animal experiments were approved by the Institutional Animal Care and Use Committee at the Oregon Health and Science University and all experiments were performed according to the guidelines for animal care at Oregon Health and Science UniversityWildtype C BL/6, B JRosa-Cag-spCas, (Stock #026179), and, Rosa-Cas9-Ai9tdTomato (Stock #007909) mice were obtained from Jackson Laboratories. Fah-/- mice were of the Fahu0394exon, strain on the, s, background, and were maintained on drinking water containing , mg/L NTBC (Ambeed). Mice were housed in groups of , to , animals in . . .
  

   

  

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