Self-organization of mortal filaments and its role in bacterial division ring formation

HIGHLIGHTS

• What: The authors show that treadmilling drives filament nematic ordering by dissolving misaligned filaments. Taking the bacterial FtsZ protein involved in cell division as an example, the authors show that this mechanism aligns FtsZ filaments in_vitro and drives the organization of the division ring in living Bacillus subtilis cells. The authors develop a computational model for the collective behaviour of treadmilling filaments, accounting for the kinetics of nucleation, growth and shrinkage, to study their collective dynamics. The authors focus on investigating the self-organization of FtsZ filaments, a highly conserved tubulin homologue12, widely present in bacteria and . . .
  

   

  

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