Semaphorin 5a drives melanoma progression: role of bcl-2, mir-204 and c-myb

HIGHLIGHTS

  • who: Simona D’Aguanno from the Cancer InstituteThe , metastatic specimens were obtained from the biopsies with different localization: , inguinal lymph nodes, laterocervical lymph nodes, parathyroid lymph node, subscapularis lymph node, brain and , lung metastatic lesions. We also analyzed Sema A expression in specimens from in situ melanoma lesions (early melanoma lesions devoid the basement membrane invasion) from , patients collected at the IFO-San Gallicano Dermatological Institute. Three-micrometer sections of formalin-fixed paraffin-embedded tumor samples were cut on SuperFrost Plus slides (Menzel-Gläser, Braunschweig, Germany). Immunoreactions were revealed by Bond Polymer Refine Detection in an . . .

     

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