Semisynthetic amides of amphotericin b and nystatin a1: a comparative study of in vitro activity/toxicity ratio in relation to selectivity to ergosterol membranes

HIGHLIGHTS

  • who: Anna Tevyashova and colleagues from the Gause Institute of New Antibiotics, BPirogovskaya, Moscow, Russia Institute of Biochemical Technology and Nanotechnology, Peoples` Friendship University of Russia (RUDN) have published the research work: Semisynthetic Amides of Amphotericin B and Nystatin A1: A Comparative Study of In Vitro Activity/Toxicity Ratio in Relation to Selectivity to Ergosterol Membranes, in the Journal: Antibiotics 2023, 151 of 24/Dec/2022
  • what: The aim of the research was to create new, less toxic semisynthetic polyenes with increased solubility in water, suitable for the further development of next generation antifungal drugs . . .

     

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