Sempervirine inhibits rna polymerase i transcription independently from p53 in tumor cells

HIGHLIGHTS

• who: Cinzia Caggiano from the pervirine is a pentacyclic anhydronium indole alkaloid isolated from the roots of the North American shrub Gsempervirens, Alton, (Loganiaceae)45, . The more stable salt form, i.e., sempervirine chloride, belongs to a natural products collection available at the Organic Chemistry Laboratory of the Department of Chemistry and Technology of Drugs (Sapienza University of Rome, Italy)47, . The chemical identity of the molecule was assessed by re-running H NMR, and , C NMR experiments. Sempervirine chloride: yellow solid, m.p.:, u00b0C. H NMR (CD OD, MHz, u00b0C, TMS): u03b4 (ppm)=8., (s, H . . .
  

   

  

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