HIGHLIGHTS
- who: Jina Yun from the (UNIVERSITY) have published the Article: Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling, in the Journal: (JOURNAL) of 12/Nov/2021
- what: Using intestinal organoids as a model of tissue regeneration, the authors show that SASP factors released by senescent fibroblasts deregulate stem_cell activity and differentiation and ultimately impair crypt formation. The authors report the identification of the N-terminal domain of Ptk7 as a SASP factor elevated in aging intestines, and released from senescent cells. The authors propose an impact of YAP . . .
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