Senescent vascular smooth muscle cells drive inflammation through an interleukin-1α-dependent senescence-associated secretory phenotype

HIGHLIGHTS

• who: Sarah E. Gardner and collaborators from the (UNIVERSITY) have published the Article: Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α-Dependent Senescence-Associated Secretory Phenotype, in the Journal: (JOURNAL) of September/16,/2022
• what: The authors show that senescent VSMCs establish an inflammatory SASP driven by IL-1α that may have multiple negative effects on atherosclerosis.

SUMMARY

The mitostatic effect of senescence is counterbalanced by the effects of the SASP on the local milieu. The authors find that senescent VSMCs establish a proinflammatory SASP, characterized by chronic . . .

 



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