Senolytic drugs relieve pain by reducing peripheral nociceptive signaling without modifying joint tissue damage in spontaneous osteoarthritis

HIGHLIGHTS

  • who: Tae-Hwan Gil and colleagues from the Department of Biomedical Sciences, College of Medicine, Korea University, Seoul, Republic of Korea have published the paper: Senolytic drugs relieve pain by reducing peripheral nociceptive signaling without modifying joint tissue damage in spontaneous osteoarthritis, in the Journal: (JOURNAL)
  • how: This result is consistent with data that suggests that long-term D+Q treatment starting in 6 14 and 18-month-old mice (without joint injury) did not attenuate cartilage degradation . The results showed that systemic administration of ABT263 and D+Q to aged mice reduced OAassociated pain . . .

     

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