Sequential control of myeloid cell proliferation and differentiation by cytokine receptor-based chimeric antigen receptors

HIGHLIGHTS

• who: Kyoko Nakajima et al. from the Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan have published the Article: Sequential control of myeloid cell proliferation and differentiation by cytokine receptor-based chimeric antigen receptors, in the Journal: PLOS ONE of July/27,/2022
• what: The authors aim to construct proliferation-inducing and differentiation-inducing CARs (piCAR and diCAR) with two different antigen specificities and express them simultaneously on the cell surface. The authors investigate whether the piCAR and diCAR could sequentially induce proliferation and differentiation according to the addition of the . . .
  

   

  

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