HIGHLIGHTS
- who: Guillaume Tetreau from the CNRS University of, LECA, Grenoble, France have published the paper: Serial femtosecond crystallography on in vivo-grown crystals drives elucidation of mosquitocidal Cyt1Aa bioactivation cascade, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: Besides clarifying the understanding of the Cyt1Aa bioactivation cascade, the study provides insights into how the yield (D11N, E32Q), toxic function (E45Q, Q168E) and pH sensitivity of Cyt1Aa crystals (C7S, Q168E) can be curbed by single atom substitutions, opening avenues to exploit recombinant Cyt1Aa variants as improved mosquitocides with increased production yield, extended target spectrum and improved . . .
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