Serpina3n is a novel hypothalamic gene upregulated by a high-fat diet and leptin in mice

HIGHLIGHTS

• who: Domenico Sergi from the This experiment was part of the NuGO Proof of Principle studies as previously described [55]To further investigate the regulation of serpinA N gene expression on a HFD, male C BL/ J mice (Harlan, Bicester, UK), aged , weeks, were singly housed on grid floors and fed either a HFD (60% kCal from fat) or a LFD (10% kCal from fat) (, and D B respectively, Research Diets, NJ, USA-see web site above for detailed dietary breakdown), ad libitum for , days, , , or , weeks and killed either by exsanguination or by perfusion fixation (, week . . .
  

   

  

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