Serum autoantibodies in patients with dry and wet age-related macular degeneration

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SUMMARY

    Age-related macular degeneration (AMD) is a leading cause of irreversible visual impairment and severe vision loss in developed countries, classified as early stage with medium-size drusen and retinal pigmentary changes to late neovascular (wet or exudative AMD) or atrophic stages. Serum autoantibodies that bind retinal proteins have been detected in AMD patients in much higher frequencies than age matched controls. Accordingly, in a previous study, the authors could demonstrate 2 of 15 a significant difference in IgG antibody patterns against retinal antigens between patients with "wet" AMD and healthy volunteers. Until now . . .

     

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