HIGHLIGHTS
SUMMARY
Owing to the alteration of the renin-angiotensin-aldosterone system (RAAS) and other maternal hormonal changes, systemic vascular resistance decreases during pregnancy, leading to lower blood pressure and an increase in renal plasma flow. Due to the rapid and dynamic changes in renal physiology during pregnancy, assessing renal functions and deciding on thresholds for normal and abnormal values is a major challenge in clinical practice. A recent study using electronic data from 243,534 pregnancies showed that sCr rapidly decreases from 60 μmol/L prepregnancy to approximately 47 μmol/L at 16-32 weeks . . .
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