Sestrin2 mediates metformin rescued the age-related cardiac dysfunctions of cardiorenal syndrome type 3

HIGHLIGHTS

• who: Migdalia Iglesias and colleagues from the Department of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, USA have published the paper: Sestrin2 Mediates Metformin Rescued the Age-Related Cardiac Dysfunctions of Cardiorenal Syndrome Type 3, in the Journal: Cells 2023, 845 of /2023/
• what: This study seeks to explore how the age-related decrease in cardiac Sesn2 levels contributes to cardiac intolerance to AKI-induced insults and how metformin ameliorates CRS3 through Sesn2. The mitochondrial respiration analysis in this study showed that mitochondrial function was indeed impaired with IR-AKI compared . . .
  

   

  

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