Setd2 supports gata3+st2+ thymic-derived treg cells and suppresses intestinal inflammation

HIGHLIGHTS

• who: Zhaoyun Ding from the (UNIVERSITY) have published the paper: Setd2 supports GATA3+ST2+ thymic-derived Treg cells and suppresses intestinal inflammation, in the Journal: (JOURNAL) of 27/Nov/2021
• what: The authors report that Setd2, a histone H3K36 methyltransferase, is important for the survival and suppressive function of Treg cells, especially those from the intestine. The authors reason that Setd2 may support GATA3 expression through translational or posttranslational mechanisms in Treg cells, although the authors cannot rule out the possibility that Setd2 may promote the GATA3 expression at the transcription level within a specific . . .
  

   

  

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