Sfrp4 promotes autophagy and blunts fsh responsiveness through inhibition of akt signaling in ovarian granulosa cells

HIGHLIGHTS

• What: This study aimed to elucidate the mechanisms whereby antagonizes FSH action. The authors report that SFRP4 antagonizes FSH activity not through the expected CTNNB1mediated mechanism, but rather though suppression of AKT/FOXO1, and also define it as a novel regulator of autophagy in mouse ovarian granulosa cells. The authors show that SFRP4-mediated induction of autophagy does not appear to involve CTNNB1, but rather occurs via a signaling mechanism resembling a recently-elucidated GSK3β-AMPK pathway used by WNT3a to regulate autophagy in neurons . This study provides novel insight into the mechanisms of SFRP4 action in . . .
  

   

  

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