Sh2 domains: folding, binding and therapeutical approaches

HIGHLIGHTS

  • who: Awa Diop and colleagues from the Biologia e Patologia Molecolari del CNR, Sapienza Universitu00e0 Roma, Rome, Italy have published the paper: SH2 Domains: Folding, Binding and Therapeutical Approaches, in the Journal: (JOURNAL)
  • what: The authors focus attention on the different strategies employed to modulate/inhibit SH2 domains binding. In this review article, the authors analyze the current knowledge about the structural, folding stability, and binding properties of SH2 domains, their roles in the onset of pathological conditions, and the different strategies designed to modulate/inhibit the function of SH2 domains. The authors focus on . . .

     

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