Sh3 domain-mediated recruitment of host cell amphiphysins by alphavirus nsp3 promotes viral rna replication

HIGHLIGHTS

  • who: Replication et al. from the Institute of Biotechnology, University of Helsinki, Helsinki, Finland, Department of Virology, Haartman Institute, University of Helsinki and Helsinki University Central have published the research work: SH3 Domain-Mediated Recruitment of Host Cell Amphiphysins by Alphavirus nsP3 Promotes Viral RNA Replication, in the Journal: (JOURNAL) of November/17,/2011
  • what: The authors show that the nsP3s of CHKV as well as Sindbis and Semliki Forest viruses use a conserved proline-rich motif to interact with the Src-homology-3 (SH3) domain of host cell amphiphysins Amph1 and BIN1/Amph2, two . . .

     

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