Shallow whole-genome sequencing of cell-free dna (cfdna) detects epithelial ovarian cancer and predicts patient prognosis

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SUMMARY

    The four CNVs subgroups genes(4) with CNVs and CA125 575.5CA125 U/mL;(U/mL) genes 575.5 U/mL.and CA125 ≤ 575.5 U/mL; genes without CNVs and CA125 > 575.5 U/mL; with CNVs For the DFS, the six and genes with (U/mL) CNVs (RAB25, genes without CNVs CA125 ≤ 575.5PIK3CA, U/mL. The study is the first to reveal that RAB25 amamplification in cfDNA, identified by shallow-WGS, can predict EOC patient prognosis. plification in cfDNA, identified by shallow-WGS, can predict EOC patient prognosis. Using shallow WGS . . .

     

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